ESIM Chemicals

Process Development

Your processes will be developed, optimized and prepared for commercial production at our state-of-the-art research and development center in Linz, Austria. In addition to the full range of standard process development technologies, it is equipped for high throughput experimentation. There is also a complete in-house analytical lab for in-time or online investigation/observation of reactions. Most importantly, the facility is staffed by a team of experts with many years of experience.

Core competences of the ESIM Chemicals process development team include:

  • Route scouting
  • Development batches (100 ml up to 10 L, in kilo lab up to 80 L)
  • Scale-up of new and existing manufacturing processes
  • Know how in up scaling of micro reaction technology and flow chemistry
  • Transfer and implementation of new processes coming from customers and implementation of ESIM-internal manufacturing processes
  • Troubleshooting of development issues
  • Improvement of existing manufacturing processes

Once your process is developed it will be scaled-up for production. This includes risk assessments, proven acceptable range (PAR) studies and validation of analytical methods and the manufacturing process. If needed, our QA / regulatory compliance team can provide all the data and support you need for a submission.

ESIM Chemicals offers capabilities in a broad range of reaction classes:

  • Halogenation using chlorine, bromine, iodine, N-chloro succinimide, N-bromo succinimide
  • Nitration / esterification using nitric acid
  • Homogeneous and heterogeneous catalytic hydrogenation (up to 14 bar)
  • Reduction using hydrides (NaBH4) and metals
  • Reductive amination / alkylation
  • Friedel-Crafts alkylation / acylation
  • Syntheses using hydroxyl amine and hydrazine hydrate (oximes, hydrazones, hydrazides)
  • Palladium catalyzed C-C formation (Suzuki-coupling)
  • Diazotation
  • Low-temperature reactions (as low as -25°C)
  • Enzyme-catalyzed reactions
  • Polymerization reactions
  • Flow chemistry using microreactors
  • Metathesis
  • Carbonylation
  • Decarboxylation