Process Development
Your processes will be developed, optimized and prepared for commercial production at our state-of-the-art research and development center in Linz, Austria. In addition to the full range of standard process development technologies, it is equipped for high throughput experimentation. There is also a complete in-house analytical lab for in-time or online investigation/observation of reactions. Most importantly, the facility is staffed by a team of experts with many years of experience.
Core competences of the ESIM Chemicals process development team include:
- Route scouting
- Development batches (100 ml up to 10 L, in kilo lab up to 80 L)
- Scale-up of new and existing manufacturing processes
- Know how in up scaling of micro reaction technology and flow chemistry
- Transfer and implementation of new processes coming from customers and implementation of ESIM-internal manufacturing processes
- Troubleshooting of development issues
- Improvement of existing manufacturing processes
Once your process is developed it will be scaled-up for production. This includes risk assessments, proven acceptable range (PAR) studies and validation of analytical methods and the manufacturing process. If needed, our QA / regulatory compliance team can provide all the data and support you need for a submission.
ESIM Chemicals offers capabilities in a broad range of reaction classes:
- Halogenation using chlorine, bromine, iodine, N-chloro succinimide, N-bromo succinimide
- Nitration / esterification using nitric acid
- Homogeneous and heterogeneous catalytic hydrogenation (up to 14 bar)
- Reduction using hydrides (NaBH4) and metals
- Reductive amination / alkylation
- Friedel-Crafts alkylation / acylation
- Syntheses using hydroxyl amine and hydrazine hydrate (oximes, hydrazones, hydrazides)
- Palladium catalyzed C-C formation (Suzuki-coupling)
- Diazotation
- Low-temperature reactions (as low as -25°C)
- Enzyme-catalyzed reactions
- Polymerization reactions
- Flow chemistry using microreactors
- Metathesis
- Carbonylation
- Decarboxylation