Your processes will be developed, optimized and prepared for commercial production at our state-of-the-art research and development center in Linz, Austria. In addition to the full range of standard process development technologies, it is equipped for high throughput experimentation. There is also a complete in-house analytical lab for in-time or online investigation/observation of reactions. Most importantly, the facility is staffed by a team of experts with many years of experience.

Core competences of the ESIM Chemicals process development team include:

• Route scouting
• Development batches (100 ml up to 10 L, in kilo lab up to 80 L)
• Scale-up of new and existing manufacturing processes
• Know how in up scaling of micro reaction technology and flow chemistry
• Transfer and implementation of new processes coming from customers and implementation of ESIM-internal manufacturing processes
• Troubleshooting of development issues
• Improvement of existing manufacturing processes

Once your process is developed it will be scaled-up for production. This includes risk assessments, proven acceptable range (PAR) studies and validation of analytical methods and the manufacturing process. If needed, our QA / regulatory compliance team can provide all the data and support you need for a submission.

ESIM Chemicals offers capabilities in a broad range of reaction classes:

• Halogenation using chlorine, bromine, iodine, N-chloro succinimide, N-bromo succinimide
• Nitration / esterification using nitric acid
• Homogeneous and heterogeneous catalytic hydrogenation (up to 14 bar)
• Reduction using hydrides (NaBH4) and metals
• Reductive amination / alkylation
• Friedel-Crafts alkylation / acylation
• Syntheses using hydroxyl amine and hydrazine hydrate (oximes, hydrazones, hydrazides)
• Palladium catalyzed C-C formation (Suzuki-coupling)
• Diazotation
• Low-temperature reactions (as low as -25°C)
• Enzyme-catalyzed reactions
• Polymerization reactions
• Flow chemistry using microreactors
• Metathesis
• Carbonylation
• Decarboxylation